The clinical examination for sheep ringworin was done in three sheep farms in Assiut provine (El Awamer, Bani Sanad and Assiut University sheep farm). Out of 1900 animals 48 animals were affected. Positive results of the microscopic examination of the hairs and scales were 23 (47.90%). Culturing of the specimens on Sabouraud's dextroses media revealed that Tricophyton verrucosum (26 isolates) was the main causitive agent of sheep ringwaorm. T. ment agrop < /em>hytes (5 isolates), T. soudanese (1 isolate),
Chrysosporium Keratinophilun (4 isolates) and Candida albicans (2 isolates) were recognized. Also, Saprophytic fungi, Aspergillus, Penicillum, Scopulariopsis and Alternaria were isolated. The effect of sodium chloride on dermatophytes was investigated. It was found that the addition of sodium chlorids 5% to Sabouraud dextrose agar would inhibit the growth of T. verrucosum and T.ment agrophytes by 100% and 93.3% raspectively. Also the use of sodium chloride in the treatment of induced ringworm infection in Guinea-Pigs gave good results after 10 days.