Diseased fattening buffalo calves (n=10) were examined in comparasion with clinically healthy fattening ones (n=12). The diseased calves showed fever, aneroxia. pale mucous membranes, some respiratory distress and enlargement of superficial lymph nodes. In addition ticks were found in large amount on the animal body. Stained blood films were positive for Theileria annulata. Leucopenia. lymphepenia with increased number of neutrophils. eosinophils. basophils and monocytes were found in diseased calves than healthy ones. Analysis of serum protein indicated significnat decrease in total serum proteins, non-significant increase in serum albumin and significant decrease in serum globulins in diseased calves than healthy controls. The ratio of A/G was significnatly higher in diseased calvesethan healthy control. Hypogammaglobulineamia was also observed in diseases calves.