SUMMARY The epidemiology and chemotherapy of fascioliasis in buffaloes was studied. The epidemiological studies were undertaken in slaughtered and clinically affected buffaloes. The infection rate was 14.6 and 16.04% in slaughtered and clinically affected buffaloes. In slaughtered animals two seasonal peaks were recorded in the months of September and February (25.4% and 24.2%) while the lowest (1.35) being recorded in the month of May. In clinically affected buffaloes, the highest infection rate was recorded in February and October (29.16 30%) while lowest incidence was recorded in June (1.79%). The higher incidence of fascioliasis was recorded in adult buffaloes (20.9%) than youngsters (13.4%) and non lactating (18.29%) than lactating buffaloes (12.70%). The results of therapeutic trials by using triclabendazole and oxyclozanide indicated that both these compounds were equally effective in the treatment of fascioliasis.