Three groups of adult Newzeeland white rabbits were used in this study. The first group served as control. The second and third groups were injected intravenously with a single dose of diazepam and ketamine respectively. The animals were sacrificed one week after injection. The specimens taken from diazepam treated animals showed a marked thickening of the glomerular and proximal convoluted tubules basement membrane, thickening of the measangial matrix, fusion of the podocyte foot processes and presence of numerous lysosomes in the cytoplasm of the proximal convoluted tubules. In case of ketamine treatment, the specimens showed fusion of podocyte foot processes and numerous vacuoles in the distal convoluted tubules.