SUMMARY This study was carried out on 42 diseased calves suffered from severe Keratoconjunctivitis and 20 apparently clinically healthy calves as control group. The main clinical signs of the infected eyes were epiphora, conjunctivitis, Keratitis, intense lacrimation, superficial and deep extensive corneal vascularization and corneal scar. Moraxella bovis formed the main bacterial causative agent, it was isolated and identified from 71.42% and 10% in both infected and clinically healthy eye swabs respectively in pure form. Staphylococcal, Streptococcal species and E. coli were isolated either in pure or in mixed form with M, bovis. Local treatment with antiseptic solutions, antibotic drops and ointements in paralel with systemic antibiotics was sucssed to releive the disease in 92.9% of infected eyes, while it was of no value and fails in 7.1% when the corneal scar was formed.