SUMMARY This study was carried out on 30 buffaloes aging (1-7 years) clinically affected by oedematous skin disease in different locality in Assiut Governorate. The clinical signs of affected animals has been described. The isolated organism in this investigation was one isolate of Streptococus faecalis (3.33%) and 25 isolates of Corynebacterium ovis (83,33%) which represent the main cause of this disease. In refering to the effective treatment of affected animals, sensitivity test was carried out on various types of antibiotics. The isolated organisms were hightly sensitive to Gentamycine, Cephalothin, Rifampicine, Erthromycin and Chloramphenicol. The hygienic measures in cantrolling the disease was discussed.