SUMMARY This study was carried out on 1000 ewes (800 from El-Hawatka Farm and 200 from different rural areas at Assiut Governorate) 2-6 years old. From clinical examination 60 ewes showed palpable enlargment of one or more superficial lymph nodes, and anthor 36 showed severe emaciation. C. psudotuberculosis was isolated from 98.3% of abscesses of external superficial lymph nodes. Internal abscesses were observed in 83% of necropsied sheeps with severe emacition, and C.psudotuberculosis was isolated form 93% of abscesses. Prescapular and bronchial lymph nodes and lung were most commonly effected organs. Other pyogenic agents such as Streptcocci, Staphylococci; E.coli and C. pyogens were also isolated, either in association or not with C.pusedotuberculosis.