In new born and five days old of control rats the white matter was cellular. The amount of cells started to decline by age ten days and the amount of nerve fibers gradually increased. So by the adult stage, the white matter contained mainly interlacing network of nerve fibers. Under the effect of alcohol, the white matter delayed in demarcation from the granular layer after ten days old. Neuronal degeneration appeared at five days old increased with age and at 21 days many spaces were found. In the adult stage all the dendritic network was dilated and showed localized thickenings. Morphometric study revealed that the thickness of white matter was decreased than the control in all ages especially at 21 days old. The anterior lobe was found to be more affected than the posterior lobe.