Sheep and goat pox viruses were isolated, from naturally infected sheep and goats, on chicken embryo, lamb testicle cells and bovine kidney monolayer fibroblast cells. Also they were identified by IFA technique, neutralization test and AGDT using hyperimmune serum against sheep and goat pox viruses. These tests indicated that there is a cross reaction between the two isolates. While when these tests applied using hyper immune sera
against parapox (ort) virus, goat pox isolate was found to be serologically related to parapox virus and no relationship was detected with sheep pox isolate.