Detomidine either 10,20 or 40 ug/kg was administered intravenously alone or in combination with butorphanol in 3 different doses (25,50 or 75 ug/kg) in donkeys. The levels of sedation and analgesia were graded and recorded. Sedation and analgesia were mostly dose dependent. Detomidine at a dose rate of 20 ug/kg together with butorphanol in a dose of 50 ug/kg produced optimal sedation and analgesia with mild ataxia. It is concluded that detomidine/butorphanol combination accentuates the degree of sedation and analgesia as well as minimize the adverse effects of both drugs.