This study was carried out to investigate the toxic and hazardous effects of sodium fluoride (NaF) on chickens. One hundred and seventy Balady broiler and sixty laying hens have been used in this study. Three experiments were conducted to achieve this goal. In the first experiment, two groups of balady chickens were fed on two doses (1000 and 1500 ppm) of NaF and third group served as control for three months. In the second experiment, two groups of white high line laying hens were used the first group was treated with 1500 ppm NaF while the second was kept for three months as control. In the third experiment, balady broiler chicken previously intoxicated by sodium fluoride (1000, 1500 ppm) for three months were used and treated with alluminum oxide. Hematological picture and biochemical analysis of Fluorine, Calcium, Phosphorous, Magnesium, Iodine, Triiodothyronine (T3), Thyroxine (T4), Alkaline Phosphates activity, and Triglycride revealed highly significant variation than normal. Also, mean egg weight, feed consumption, and body weight gain were decreased. The use of aluminum oxide has some beneficial effects for treatment of florine toxicity in broiler chicken.