Inactivated formalinized tissue vaccine was prepared locally from liver suspensions of rabbits infected with rabbit haemorrhagic disease virus. Thirty two california rabbits, 2 month old were inoculated subcutaneously with local and imported vaccines. (16 rabbits for each vaccine). Haemagglutination inhibiting antibodies were determined in both vaccinated groups 2, 4, 6, 8 and 10 weeks post vaccination and showed that rabbits vaccinated with local vaccine gave higher antibody titer than rabbits vaccinated with imported vaccine. Both an inactivated vaccine either locally prepared or imported gave full protection against challenge with rabbit haemorrhagic disease virus at 4 days, 3, 6 and 9 weeks after vaccination in comparison with 100% mortality of unvaccinated control rabbits.