A total of 76 camels, 4-8 years old were involved in this study. Twenty camels were clinically healthy and kept as control, however the rest of 56 camels were coming from the Daraw quarantine (Daraw city, Aswan Governorate) by means of trucks for marketing in the villages of Assiut Governorate. These camels were exposed to the stressors of transport, climatic and dietary changes. They showed gastrointestinal upsets. Clinical, haematological, biochemical, microbiological and therapeutical investigations were the main objects of this work. Clinical examination of diseased camels revealed intermittent passage of soft faeces to severe watery diarrhoea, weakness, partial loss of appetite, loss of weight and depression. According to the severity of the signs, the camels were classified into two groups. Group 1: Mild to moderate diarrhoea (30) and group 2: Severe diarrhoea (26). Marked macrocytic hypochromic anaemia and leucocytosis were observed in both groups. Significant decrease in blood serum Nat, CL, P, Mg and glucose and significant increase in serum K were noted in all diseased camels. Bacteriological findings of faecal swabs of group 1 revealed E. coli (21.4 %), Proteus mirabilis and E. coli (3.6%), Pseudomonus aurogenosa & E. coli (21.4 %), Pseudomonus aurogenosa & Proteus morgani (3.6 %) and Pseudomonus fluorescence (3.6%). However 14.3 % of this group were also infested with Trichostronglus and Cappillaria spp < /em>. In group 2, the microbial findings were Salmonella typhi and E. coli (14.3 %), Kliebsiella & E. coli (7.1 %), Actinobacillus & E. coli (10.7%) and Sporothrix shenkii & E. coli (14.3%). Eimeria cameli (25 %), Trichostrongylus and Eimeria cameli (3.6 %), Trichostrongylus and Haemonchus spp < /em>. (7.1%) and Haemonchus spp (3.6 %) were the parasites recognized in this group. According to the parasitological findings, bacterial culture and sensitivity, therapeutic trails were achieved. Oral antidiarrhoeal mixture containing sulphamethasine was given twice daily for 5 days and parentral administration of Gentamicin sulphate (5 mg / kg b.w), 2 times daily for 5 days) for all diarrhoeic camels except those suffering from salmonellosis, where they treated parentrally with thiophenicol (20 mg/kg b.w). Ivermectin was injected abcutanously for camels suffering from parasitic infestation (1 ml/50 kg b.w). Mineral mixture and multivitamins were also given as a supportive treatment for diseased groups. All camels were gradually recovered except only two camels of group 2 were succumbed.