The present study involved clinical and laboratory investigations of 42 fattening cattle and buffalo-calves, 8-24 months old and belonged to fattening stations, small private farms, veterinary clinics and abattoirs. 22 out of them were suffering from ruptured urinary bladder and/or urethra and the rest of 20 were clinically healthy and kept as control. The present study declared that long standing obstruction of urinary passages (2-3 days) especially when the stones were lodged in penile urethra resulted in complete retention of urine, and may precedes to urethral or urinary bladder rupture. Disappearance of colicky pain and other signs of obstructive urolithiasis, followed by bilateral swelling on the ventral abdomen, near the root of the penis and around the scrotum were the main signs observed in ruptured bladder and / or urethra. Reddish or bluish discolouration of the infiltrated areas and ammoniacal breath with lethargy, depression, weakness were also the main consequent symptoms. Puncture of the lower abdomen revealed passage of urine from the peritonial cavity. Rectal examination confirmed the diagnosis, where the bladder was empty with flabby wall. The obtained urine were mainly dark yellow, turbid with increased specific gravity. Urine sediments were composed mainly of crystals of triple and amorphous phosphates, calcium-oxalates and calcium carbonate with 27 Assiut Vet. Med. J. Vol. 39 No. 78. July 1998 increased amounts of pus and red cells. Significant increase in the levels of blood serum urea, creatinine, phosphorus, calcium and magnesium were noted, however blood serum chloride was significantly decreased. Insignificant difference were recorded in blood serum levels of vitamin A vitamin E, AST, ALT, total lipid, cholesterol and triglyceride. Significant increase of PCV, total leucocytic count and neutrophils were markedly seen. The blood serum protein pattern showed only slight insignificant changes. Isolated bacteria were mainly E. Coli and Staphylococci. Stone analysis revealed that struvite (magnesium,ammonium phosphate) uroliths were found pure in 4 cases and in association with traces of calcium carbonate in 2 cases, while ammonium silicates, oxalate and little phosphates were found in two cases. Finally the study declared that urolithiasis with its subsequent complications such as urinary bladder and /or urethral rupture come in the first line among the common urinary tract disorders in fattening calves and contribute to a serious managemental, medical and economical hazards for beef industry