The present work was designed to infect rabbits experimentally with E. granulosus eggs and to study the location of hydatid cysts in these rabbits as well as the appearance of specific antibodies in their sera. Macroscopical examination of all internal organs and different muscles of the experimentally infected rabbits 13 weeks post-infection revealed livers and lungs only. cysts in presence of small hydatid the Microscopically, these cysts contained protoscolices. Sera from the infected rabbits were used to evaluate the diagnostic sensitivity of E. granulosus eggs and purified hydatid fluid (arc 5) antigens by ELISA. The antibody levels appeared at 5 and 3 weeks p.i. with eggs and arc 5 antigens, respectively. The antibody levels increased gradually till 8 weeks p.i. and nearly remained in constant levels till 13 weeks p.i.(end of experiment). The arc 5 antigen gave optical density (O.D.) higher than that of the eggs indicating high levels of sensitivity. weeks Piment). The arc 3 anish levels of sensitiv