A herd of 78 raising sheep at Sohag Governorate appeared suffering from drowsiness, rapid shallow respiration and 9 % mortality rate. The necropsy findings were frothy fluid from the mouth and nose, subcutaneous congestion and haemorrhages, hydroperitonium, hydrothorax and hydropericardium. Hepatic focal areas were the constantly observed. The histopathological lesions included cell dissociation, coagulative necrosis and cellular infiltration. Gram positive bacilli were also noticed in necrosed areas. Telangiectasis was also a prominent feature. The lesions could be attributed to the toxins of clostridial infection.