ABSTRACT   The present study was conducted to evaluate the effects of propolis on performance, immune response and meat quality of broiler chickens infected with E. coli. A total of 120 day old chicks were divided randomly into 4 equal experimental groups. The 1^st group (G₁) was fed a basal diet and infected with E. coli (1x10⁸ CFU) at 5 days of age. The 2^nd group (G₂) was fed a basal diet supplemented with propolis (400mg/kg diet) and infected with E. coli (1x10⁸ CFU) at 5 days of age. The 3^rd group (G₃) was fed a basal diet supplemented with propolis (400mg/kg diet). The 4^th group (G₄) was fed a basal diet and served as a control. Propolis supplemented groups showed a significantly increased body weight, decreased mortality, decreased reisolation frequency of E. coli from internal organs and early recovery of infection. Propolis improved significantly the phagocytic activity in both supplemented groups. Total leukocytic count was significantly increased in propolis supplemented group with significant increase in lymphocytes and concurrent decrease in heterophils. Propolis improved the Newcastle disease vaccine antibody production in both supplemented groups. Propolis treated groups have significantly higher breast muscles protein concentration and lower fat content. Also, it showed a significant reduction on the bacterial load in the examined samples in comparison to the samples of the non supplemented groups.