This study was conducted toward a problem of extend early mortality of ducklings. A total of 100 freshely dead and clinically sick ducklings of different ages (1-21 days) and types obtained from private farms at Dakahlia Governorate and also cases which arrive to the Mansoura lab. The samples were dispatched to the laboratory to be examined bacteriologically for detection of the actual bacterial causes of early mortality problem in these farms. The obtained results pointed out that a total of 144 isolates were isolated. All the bacterial isolates were identified morphologically, culturally, biochemically and serologically for E. coli and Salmonella microorganisms. Pseudomonas aeruginosa was the most prevalent bacterial agent 35 (24.30%) followed by E. coli 25 (17.37) , Salmonella and Staphylococcus aureus 20 (13.89%) for each, Klebsiella pneumoniae 16 (11.11%), Riemerella anatipestifer 15 (10.42%) and Proteus vulgaris 13 (9.02%). The isolated E. coli were identified serologically into 7(O₇₈K₈₀(B-), 6(O₈₆K₆₁(B7), 5(O₁₂₅K₇₀(B15) and 7 (untypable), while the recovered Salmonella strains were identified into 12 Salmonella typhimurium and 8 (untypable). In-vitro-sensitivity pattern of isolated strains proved that ciprofloxacin, enrofloxacin, gentamycin  were the most effective drugs.