The present investigation aimed to set up a preliminary data for plasma thyroid hormones in desert goats and the corresponding haematological parameters. For this purpose, a total of 50 apparently healthy goats at different ages, sexes, reproductive and productive status were selected from their natural habitat in the peri-urban areas at Al-Wadi Al-Gadeedgovernorate. The obtained results revealed that the all-mean values of plasma triiodothyronine (T₃) and thyroxin (T₄) were 109.650±6.167ng/dl (49-210) and 4.703±0.197ug/dl (2.1-7) respectively. The haematological investigations revealed that the mean values of red blood cells (RBC) x10⁶/ul, haemoglobin (Hb) g/dl and packed cell volume (PCV%) in desert goats were 6.610±0.183 (4-8.4) x10⁶/ul, 7.473±0.158 (5-9.4) g/dl and 24.255±0.436 (19-30)% respectively. The mean values of T₃, RBC, Hb and PCV were increased by increasing age of animals. Sex had non-significant effect on all studied parameters in young animals < 6 months, while the values in males were significantly higher than females in older individuals. The mean values of the studied parameters were significantly varied in pregnant individuals if compared with lactating and stagnant goats. The mean values of both non-pregnant non-lactating and lactating individuals were non-significantly varied. the present investigation demonstrated different degrees of variations in the plasma thyroid hormone concentrations and haematological parameters in goats raised at Al-Wadi Al-Gadeed area under the effect of age, sex, reproductive and productive status.