Five of one humped camels of about 6 years in age and 550 kg in weight were used in this investigation. Animals appeared to be clinically healthy and parasitological examination revealed no gastrointestinal affections. The five animals forming one group, were used in four trials alternating in intentionally testing sequence. Trial one was used as control and animals were fed for seven days on the control diet. Trial one followed by three trials of successive periods of feed and water deprivation (trials 2, 3, and 4). Each period of deprivation was interrupted by a phase of 4 days refeeding. During feeding period, all animals were fed as group on commercial concentrate mixture (1.5 kg/head/day), barseem and wheat straw adlibitum. In addition, additives were added daily to the concentrate mixture at a level of 0.14 kg/head/day. Animals were cleaned out periodically to prevent them from eating their dung. On the last day of all the trials, experimented camels were examined clinically to determine their health status. Dry matter and water intake as well as changes in the body weight were recorded. Changes in the digestibility of different nutrients after different periods of deprivation were also estimated. Moreover, blood serum was analyzed for some biochemical parameters. Ingestive behavior of the experimented camels was recorded within the first hour on the last day of the control and the first day of refeeding periods. The obtained results revealed that, prolonged deprivation of food and water appears as a stress factor on camels with a clear and obvious effect on their health status, nutrients digestibility, water intake, body weight, some behavioral and biochemical parameters. This suggests that any prolonged water and food deficit among housed camels must be corrected.