The study was carried out during an outbreak of LSD in the period from June to September 2005. The affected animals were kept in a small holder groups in different localities in Damietta Governorate. Clinical signs were described in detail. Fever, anorexia, depression, agalactia, multiple skin nodules are distributed anywhere allover the body, enlargement of superficial lymph nodes, odema of the dependent parts particularly the limbs were the most common signs in diseased cases. Based on the severity of the clinical signs, the diseased cases were classified into 3 groups. The first group was treated by antibiotic 215 Assiut Vet. Med. J. Vol. 52 No. 109 April 2006 (Amoxycillin L.A) and non-steroidal anti-inflammatory drug (Declophenac sodium) for 7-10 consecutive days. One shot treatment was found effective in the second group, while the third group (inapparently affected) can overcome the disease without treatment. Septic lesions met with in some cases were treated surgically. The main objective of this study is to find out a guide line for management of LSD to prevent or minimize its complications and losses.