Postpartum in buffaloes plays a great role in delay of the cyclicity in buffaloes that seemed to be anestrous. So, the use of hormones to induct estrus or induct ovulation has an importance to increase pregnancy rate. The present study was designed to evaluate the efficacy of the two methods in inducing high pregnancy rate. The experimental animals (48 lactating buffaloes) were divided into three groups: PGFza group 1(n=16); Ovsynch group 2 (n=16) and control group (n=16). Pregnancy rate was significantly (p < 0.001)increased in group 2 than group 1 and control group due to higher level of progesterone and more accurate synchronization for ovulation., It is more suitable to use the regimen of ovsynch in postpartum buffaloes especially in multiparous females with good condition score.