The objective was to describe the radiographic changes that may reflect the diseased conditions of the sesamoid bone in working donkeys under local circumstances. Sesamoditis and fractures were diagnosed by using survey radiography in 21 limbs. The radiographic appearance in case of sesamoditis, was variable, ranging from a number of lucent areas along the non-articular surface of the bone with some new bone formations, to an extensive new bone formation on the non-articular surface of the bone. Depending on their radiographic appearance sesamoid bone fractures were classified as basilar, transverse and abaxial. In most cases of sesamoid bone affections there were extensive new bone formations that may result from the associated inflammation of the periosteum and sesamoid ligaments.