The incidence of Campylobacter jejuni and Campylobacter coli harbouring the intestine of sheep with diarrhea was studied . A total number of 100 rectal swab samples were collected from sheep suffering from diarrhea at Alexandria governorate animal inclosures . The samples were examined bacteriologically . The bacteriological examination revealed the isolation of Campylobacter jejuni from 12 (12 %) out of 100 examined sheep ,while Campylobacter coli could be isolated from 9 cases of diarrheic sheep examined . Moreover , Campylobacter isolated in this study were tested for susceptibility of 10 antibiotics . None of the isolates were resistant to Chloramphenicol and high percentages of isolates were resistant to Tetracycline , Penicillin and Sulphamethoxzole . These results indicate that Campylobacter colonization in the intestine is very common in sheep and the bacteria play a role in aggravation of diarrhea process . The public health importance of Campylobacter jejuni and Campylobacter coli were discussed .