Eighty 21-days-old quails were randomly distributed into four experimental groups each of 20 birds and fed ration containing 0 (control), 16 ppm ochratoxin, 16 ppm ochratoxin + 2gm/kg humin feed and 2gm/kg humin feed. Each treated group was replicated twice of 10 quails. Quails fed for a period of 4 weeks 16 ppm, ochratoxin showed reduced body weight, poor feed conversion ratio compared with control and other groups as well as reduces total RBCs count, hematocrite value and hemoglobin content. No differences were found among leukocytes counts in all groups when compared to control, a lower percentage of lymphocytes was observed in birds fed 16 ppm ochratoxin. GOT, GPT, uric acid and creatinine were higher in birds fed 16 ppm ochratoxin indicated the hepatotoxic and nephrotoxic effect of ochratoxin in quails. Histopathological examination of kidneys, liver, spleen and bursa of birds fed 16 ppm ochratoxin confirm the toxic effects of ochratoxin in quail. The performance indices, hematological, biochemical and histopathological results indicated that humin feed is efficient in counteracting the toxic effects of ochratoxin fed to quail.