The present study was carried out to investigate the effect of aflatoxin contamin-ated feed on male fertility and some biochemical parameters in male rabbits and modulating this effect by using gensing.A total 60 of apparently healthy adult male baladi rabbits (8-10 month of age) and 2.5-3 kg b.wt., were divided into four equal groups, 1^st group was left without treatment as control, 2^nd group was fed on a ration containing 1 mg aflatoxin /kg for 60 successive days, 3^rd group received 200 mg/kg body weight of gensing extract dissolved in saline solution orally through mouth tube for 60 successive days and 4^th group was fed a ration containing 1 mg aflatoxin /kg and received 200 mg/kg by using mouth tube for 60 successive days. Five rabbits from each groups were slaughtered at 1^st, 30^th and 60^th days post medication. Blood and semen samples were collected from control and treated rabbits.Blood samples were used for biochemical analysis. Semen samples were collected from tail of the epididymis to evaluate semen character. Aflatoxin elucidated significant reduction on sperm cells concentration, progressive motility and live sperm but increased total abnormality percent at 1^st and 30^th days post aflatoxin medication. Gensing induced significant increase in sperm cells concentration, progressive motility, live sperm and decreased total abnormality percent at 1^st and 30^th days post treatment. Rabbits received both aflatoxin and gensing induced non significant effect on sperm cells concentration, progressive motility, live sperm and total abnormality percent. Aflatoxin induced significant decrease in testosterone hormone level, weight of secondary sex organs (testis, seminal vesicle and prostate gland), total protein and significant elevation in serum transaminases (AST-ALT) and alkaline phosphatas at 1^st and 30^th days post feeding on aflatoxin.Gensing induced significant increase in the level of serum total protein, testosterone hormone but ALT, AST and alkaline phosphatas non significantly effect. Aflatoxin and gensing induced non significant effect in the above biochemical parameters. It could be concluded that aflatoxin induced many reversible alteration in male fertility, hormonal and some biochemical parameters as they returned to their normal values 60^th day after stoping aflatoxin addition. Gensing minimize or reduce the alteration in fertility and biochemical changes induced by aflatoxin.