A survey of the prevalence of Pasteurella haemolytica (P.haemolytica) in ducks in Assiut governorate was carried out on 250 birds from different duck farms.Bacteriological examination and biochemical tests revealed isolation of P.haemolytica at a rate of 4 %. Clinical signs of living ducks showed depression, loss of appetite,diarrhea and respiratory symptoms (coughing and a watery nasal discharge). Postmortem examination revealed pneumonia,airsacculitis and congestion of the liver with necrotic foci. Histopathologically Abundant amounts of bacterial organisms were present in some organs appeared as Gram negative cocoobacilli in sections stained by Gram's stain. Liver, kidneys, myocardium and lungs showed inflammatory reactions together with vascular changes represented by edema, hyalinization of the central vein of hepatic lobules, thickening in the wall of hepatic sinusoids and segmental necrosis of glomerular tufts The renal tubular epithelium was desquamated. The myocardium showed coagulative necrosis. The lungs showed atelectasis of many bronchioles and alveoli. In-vitro- sensitivity test revealed that danofloxacin, gentamycin and trimethoprim were the most effective drugs against isolated organism.