This study aimed to evaluate the correlations of plasma protein and electrolytes in the desert goats suffering from internal parasites under the effect of hot dry environment in the Egyptian oasis. According to parasitological examination, 60 male goats (8-10 months) were selected during the temperate climate (March) and a similar number of age-matched male goats were selected during the hot-dry climate (July) 2006. Each group of the selected goats was divided equally into 3 sub-groups (20 each). The first harboured gastrointestinal nematodes (GIN), the second was suffering from fascioliasis and the third was clinically healthy, which served as control. Blood samples were drained from all goats for estimation of plasma proteins and electrolytes concentration. All goats with GIT parasites had a significant reduction in concentrations of plasma total protein, albumin and A/G ratio compared with control ones. The reduction was more severe in goats suffering from fascioliasis. During hot-dry climate, goats with internal parasitism had higher plasma sodium than in control group during the same climate and than in the corresponding parasitized groups in the temperate climate. Pearson's correlation coefficient (r), linear regression equation and the regression factor (R²) revealed a significant negative correlation (r= -­­ 0.56, R² =0.32 P=0.002) between plasma sodium and albumin concentrations in goats reared under hot-dry conditions, suggesting that the desert goats infected with GIT parasites try to adapt to the hot-dry weather throughout retaining body water. This mechanism is characterised by a state of selective sodium retention against the obligatory depletion of albumin due to internal parasitic infection