The present study was performed to evaluate the concurrent use of toltrazuril and amprolium plus in treating avian coccidiosis. Two hundred one day old Hubbard broiler chicks kept in wire floor batteries under hygienic measures were used. On day 19^th of age chicks were aliquated into five groups, 40 each (1^st group served as negative control, 2^nd group served as positive control, 3^rd group was infected and treated with toltrazuril 25 mg/L of drinking water, 4^th group was infected and treated with Amprolium plus 250 ppm in ration and the 5^th group was infected and concurrently treated with toltrazuril 25 mg/L and amprolium plus 250 ppm in ration. Treatment usually started 3 days post infection, chicken in all groups were weighted at 20, 27, 34 and 41 day of age. Body weight gain, feed consumption, feed conversion, mortality, lesion score was determined. Oocyst count was performed 2, 6, 11, 16 and 21 days PI. On the 40^th day of age, 5 birds from each group were weighted, slaughtered and had bursal body weight index determined. Blood samples from slaughtered birds were divided into two portions, one for serum preparations for serology and clinical chemistry parameters, while the other portion was collected on EDTA for hematological study. 10 of the remaining birds from each group were subjected for virulent Newcastle diseases challenge. Results obtained showed that tolrazuril and amprolium plus administration individually at the therapeutic doses had valuable effect in the treatment of avian coccidiosis and simultaneous administration of both drugs had more potent curative effect and less effect on liver and kidney function parameters, meanwhile non of the used drugs proved immunosuppressive.