Fourty male albino rats, were divided into four separate groups each of 10 rats. Group I was considered as control. Rats of other groups Gr II; III and IV were intoxicated by lead acetate at a dose of 0.5 gm /100 ml in drinking distilled water for 63 days (Gr 11), in addition of casein at a concentration of 20 g / 100g ration in (Gr III), and activated charcoal in a concentration 0.05 g / 100g ration in (Gr IV). Exposure to lead acetate in Gr II resulted in suppressed spermatogenesis and hormonal levels in serum (testosterone, FSH and LH) with a highly significant decrease in weights and size of sexual organs as compared to the control (Gr I). The pathological changes of sexual organs in lead treated rats showed severe degenerative changes in the epithelium tubules. On the other hand these patholoigical investigation were improved in (Gr III) in casein treated rats. The results of immunological studies showed suppression of antioxidant levels lysozyme activity and nitric oxide production as         a result of lead exposure in rats (Gr II). There was also a marked increase in malondialdehyde production as a result of lipid peroxidation. Kidney function and liver enzymatic activity were increased in Gr II as compared to Gr I In addition, the immunological studies revealed a significant decrease in serum total protein, gamma globulin and serum albumin as a result of immunosuppression effect of lead in Gr II. After treatment by casein or charcoal, it is obviously clear that casein can induce protective effects against lead toxicity nearly in most reproductive parameters and immunological states, while charcoal failed to improve the toxic effects of lead.