The present investigation was carried out to clearify the efficacy of Albendazole at dose rate 15 mg/kg b.wt. and Mirazid (Commiphora Mol-Mol or Myrrh)at dose rate 10 mg/kg b.wt in treatment of fascioliasis in cattle. The results revealed that Albendazole resulted in efficacy 100% but in the 5^th week post-treatment, reshedding of eggs in the faecees occurred, meaning that Albendazole is effective against mature flukes only. However Mirazid revealed that it is effective at 5^th week until 12^th week and its efficacy was 90% and 85% in 3 successive days or 6 successive days doses of treatment, respectively. It is concluded that Mirazid proved to be effective anti-fascioliasis drug but need development to prolonged times of administration of the drug.