The object of this study was to detect the fatal dose of half  animals of this experiment (rabbits) LD50 from the 10% concentration of alcohol abstract of the fruits of Ecballium elaterium and studying of the effect of introducing fifth of LD50 on direct bilirubin and total bilirubin and the weight changes in rabbits. The study was performed at white rabbits of both gender with proximate weights, LD50 was determined in 24 hours by Behrens and karbars method so we have found that it was 780mg\kg, Then we have studied the chronic effections of the abstract by giving rabbits fifth of LD50 daily and orally for five weeks, at the end of the experiment we found that it caused a significant increase in (RBC), (MCV), (MPV), and un significant increase in (WBC), (HGB), (HCT), ( %LYM), (GRA%), While clear significant increase in (MON). On the other side, (MCH) and (MCHC) had clear significant decreased.