Hemogram, haptoglobin and clotting factors indices were evaluated in local buffaloes breed affected with acute and chronic peritonitis in, Mosul -Iraq. Fifty one local buffaloes breed  ,3-10 years old, of both sexes were studied in this study .Among these animals (16) were affected with traumatic reticloperitonitis (TRP), (8) animals suffering from acute ruminitis due to ruminal overload, (6) animals were suffering from severe tympany that needed trocarization and (10) showed sings of chronic peritonitis as a sequel of ruminatomy. Eleven clinically normal local buffaloes breed were served as control group. Results indicated that clinically diseased buffaloes exhibited different clinical sings which were varying in degree with the severity and extent of the peritonitis. Statistically significant increase (p < 0.05) was encountered in PCV and TLC in animals exhibited acute peritonitis. Animals affected with acute peritonitis showed nutrophelia(Band type nutrophils were increased in cases of TRP only ,whereas mature type were increased in all animals showed acute peritonitis), and lymphocytopenia. Eosinophelia were indicated in buffaloes affected with acute ruminitis and monocytes were increased significantly in animals affected with chronic peritonitis. Results also showed significant decrease (P<0.05) in the mean values of total platelets count in buffaloes affected with acute peritonitis compared with normal control and animals affected with chronic peritonitis .Values of mean platelets volume, platelets distribution width, , prothrombin time and partial thrombpplastine time were increased significantly (P<0.05) in animals affected with acute peritonitis. Clotting time was only increased significantly (P<0.05) in animals affected with TRP. Serum values of fibrinogen and habtoglobin in control and diseased buffaloes indicated significant increase of fibrinogen (P<0.05) in all diseased animals whereas habtoglobin increased significantly (P<0.05) in animals affected with acute peritonitis.