The current study was carried out 330 Egyptian Balady goats from both sex, aged 1-2 years from different localitied at Assiut governorate. The clinical examination revealed that 60 (18.18%) have enteritis with signs of diarrhea of different degrees, anorexia, loss of appetite, depression and slight emaciation and the remaining goats were apparently clinically healthy. 60 rectal swabs were taken from clinically diseased goats for bacteriological examination which revealed that the main isolates were E.coli 59(98.3%) and Salmonella 1(1.67%). The isolated E.coli strains were identified serologically into 10 strains and 39(66.10%) untypable strains. The isolated salmonella strain were identified serologically into 1(1.67%) salmonella enteritidis. Antibiogram for the bacterial isolates revealed that the best sensitive antibiotics were rimactan, chloromphenicol and garamycin. Blood serum biochemical analysis in diseased cases showed significant (p < 0.05) decrease in glucose and total protein levels in diseased cases. Also, the study aimed to knew the effect of bacterial enteritis on the blood gases, acid-base balance in heparinized blood and serum electrolytes of both clinically healthy and diseased goats. There were a marked decreased in mean values of blood pH, significant decrease in values of HCo₃, TCo₂, B.E. sodium and chloride as well as significant increase in potassium level in clinically diseased goats when comparison with the control group.