A total of138 whole blood and serum samples were collected from camels (Camelus dromedaries) aged 3~10 years, with suspected clinical symptoms of blood parasites from May to August 2011, at different middle regions of Al-Riyadh Province in the Kingdom of Saudi Arabia (Al-Riyadh, Thumamah, Dawadmi and Wadi Al-Dawasir). Clinically the suspected infected camels with anaplasmosis showed signs of pale mucous membranes, rough hair coat, lacrimation, and ticks were noticed and detected on several locations at the camel's body. A total of 32 samples (23.19%) were microscopically positive for Anaplasma marginale (with parasitaemia 3-5%). All samples were tested by an indirect Enzyme Linked Immunosobent Assay (3-ABC-ELISA) which is specific to detect antibodies of foot and mouth disease virus (FMDV) infection. ELISA results revealed that 19 (13.76%) serum samples were positive; all these samples were positive for Anaplasma marginale. Meanwhile, the animals not showed any clinical FMD symptoms. This study revealed moderate infection of Anaplasma marginale, as well as concurrent incidence of FMD among camels in KSA. It would be of great interest to know if dromedaries play a role in transmitting the FMDV.