The clinical singes of Infectious Bovine Rhinotrachitis (IBR) in cattle included rise in body temperature , keratoconjunctivitis, ulcerative lesions on  muzzle and nasal septum , salivation , lacrimation , lesions at prepuse of male and pustule at the mucous membrane of valve and vagina in females. The seroprevalence of antibodies of Bovine Rhinotrachitis virus using indirect ELISA test in calves suffering from respiratory signs with genital lesion was 67.4  % , while 72.7 %  in aborted cows and 62.5 % in cows suffering from keratoconjunctivitis . the mean of antibodies titer in calves appear respiratory singes with lesion at genitaria was 1.414 ± 0.15 in mild cases to 2.34± 0.055 in severe cases , while in aborted cows the mean titer of antibodies was 4.64 ±1.44 to 125.55 ± 8.68 in mild and severe cases respectively in cows affected with  keratoconjectivitis the mean of titer in severe cases was 65.9 ±15.96 to 121.26 ±2.66 in mild and severe cases respectively.