Brucellosis and Leptospirosis are the most symbolistic swine occupational bacterial zoonosis constitutes direct occupational hazards for manipulating employees or animals that licked or eaten the aborted fluid or membranes. Occupational workers appear to be the most risk groups of contracting the diseases from pigs. It's of ecological impact and on target zoonosis to detect the sero-prevalence of those two zoonosis in human in contact with free living swine, reflect the human bio-hazards are due to direct contact with contaminant swine subset. Pigs are naturally exposed to zoonotic agents in their subset with subsequent direct occupational human hazards. Brucella and Leptospira are infectious agents probably reflects a major bacterial hazards for human in contact with the free living swine in addition the economical drawbacks consequences to swine abortion and piglet depletion. A total of 250 free rearing pigs blood samples were collected from different localities in large Cairo governorate, Egypt. Also, 150 serum samples were collected from occupational workers. Human and swine sera were tested for antibodies against the two zoonotic diseases by using Egyptian locally serological antigens and commercial kits. Antibodies against Brucella were detected in 42% of 250 pig samples using RBPT. The most sensitive confirmatory test was SAT 37.6%.The seropositive percent of human in contact using SAT 4.7%. Antibodies against three Leptospira serovars were detected in 66.8% of the serum samples from pigs using the Microscopic Agglutination Test (MAT) at titers of 1≥200. The highest seroprevalence was recorded for L. Pomona serovar 32.4% followed by                    L. grippotyphosa 20.8% and then the lowest prevalence detected by L.icterohaemorrhagiae 13.6%. While in human 25.3% were positive with the highest incidence corresponding to L. Pomona 11.3%.