This study was designed firstly to investigate whether cypermethrin and Neocidol have effects on length of estrous cycle, estrous recyclicty and reproductive hormones in native ewes. Twenty apparently healthy mature ewes of native breed were used in the current study, sprayed by eitherneocidol or ectomin by the proper dose(1/1000 and 1/500 respectively) during the breeding season. Synchronization of estrus was performed by using veramix sheep sponges which contain medroxy progesterone acetate. The obtained results revealed that, spraying of ewes by eitherneocidol or ectomin by the proper dose(1/1000 and 1/500 respectively) during the breeding season had no impairment effect on the length of estrous cycle or estrous recyclicty. It was also noticed that the treatment of ewes with neocidol during the breeding season had no significant (p < 0.05) effect on the length of estrous cycle. Moreover, neither neocidol nor ectomin had no significant influence on the classical pattern of progesterone (P4) profiles. The obtained results showed that a similar pattern of FSH in the control, neocidol and ectomin treated ewes. This pattern was in the form of two elevated peaks on zero and first day of estrous cycle and fluctuated till the end of estrous cycle. In addition, LH pattern during estrous cycle was similar in the control and neocidol and ectomin treated ewes, one peak only was recorded at zero day in the three estrous cycles then the level was fluctuated all over the experimental period in all treated and control ewes. From the current study we concluded that neither cypermethrin nor Neocidol had adverse effects on length of estrous cycle, estrous recyclicty and reproductive hormones in native ewes when sprayed by the proper dose(1/1000 and 1/500 respectively).