This research was conducted to evaluate the effects of honey as anti bacteria on opened wounds in rabbits. Seventeen New Zealand white male rabbits were used in this research. Two 2X2 cm full thickness skin pieces were removed from rabbit's backs under general anesthesia. The two wounds were excised on both sides of the mid paravertebral back. The rabbits were divided into three experimental groups. Honey was applied twice a day on wounds of group one which contained five animals. Group two also contained five animals were silver sulfadiazine 1% cream was applied on wounds twice a day. Control group consisted of seven animals in which wounds were washed twice a day with saline dressings. The tested materials were put on wounds then covered with sterile plaster to cover the bandage dressing twice a day. Finally، wounds were assessed by histological study eight times every four days. Results from this experiment showed that activation of fibroblasts increased the formation of granulation tissue، and collagen fiber formation, decreased edema and dehiscence. It is can be concluded that honey accelerates healing of opened  wounds in rabbits.