This work aims to studying the effects of maternal derived antibodies against the live vaccines of infectious bursal disease for the chicks, and serological estimation for interference between the maternal derived antibodies and the Gomboro live vaccines which are given in the early age, as well as achieving the best vaccination program to control the disease. Group of chicks were taken from elderly parents and this was divided into five groups 24 one day old chicks/group. One of these groups was raised as a negative control, and the other four groups were given various Gomboro live vaccination (hot and intermediate vaccines) at different ages. The levels of antibodies were examined weekly, which was produced from the weekly vaccinated birds, were examined. The high levels of maternal derived antibodies have affected the given vaccines, and they interfere with the maternal derived antibodies when using the live Gomboro vaccines.