The study was carried out at Taif slaughtered house of small ruminants, KSA. It was done in period time of (2010-2012). The animals of study were sheep for the purpose of meat production in an attempt to measure the economic losses due to parasite and microbes co-infections leading to meat condemnations. Specimens were collected as liver lesions, gall bladder and flukes. Sheep were slaughtered and examined (No.=29.100), infected livers by Fascioliasis were (940) 3.2% from totally slaughtered sheep, and they were differentiated into acute cases (629) 66.9% and chronic cases (311) 33.1%. The bacterial isolates recovered from all samples were 7 types, Staph. spp., Strept. spp. E. coli,Proteus spp., Klebsiella spp., Clostridium perfringens and Clostridium novyi. In animals with acute infections the 7 types of bacteria were recovered from liver lesionsin the percentages of 15.3, 8.9, 7.6, 3.3, 2.7, 13.8 and 2.2%, gall bladder 1.2, 1.0, 15.5, 12.9, 11.1, 22.9 and 8.7%, flukes 1.4, 1.1, 14.1, 13.5, 10.7, 22.4 and 8.3% respectively. The total isolates were 53.9, 73.2 and 71.6% from liver lesions, gall bladder and flukes.Incidence of bacterial types were isolated from chronic cases from liver lesions 17.4, 10.3, 11.6, 9.6, 6.8, 17.7 and 5.8% respectively. The isolates were isolated from gall bladder 1.0, 0.6, 15.7, 9.0, 7.4, 19.3 and 7.4%, flukes were 0.6, 1.0, 12.9, 7.4, 8.4, 18.3 and 7.0%. So the total isolates 79.1, 60.5 and 55.6% were from liver lesions, gall bladder and flukes.