This study was conducted to evaluate the effect of Probiotic (primalac^®) on Cell Blood picture and on Cholesterol in lambs. Thirty lambs from the Syrian Awassi lambs, aged approximately 5 months with average body weight (32±0.7 kg) Were used in this experiment. The experiment of animals were devided into three groups: (T0, T1 and T2). All groups were fed on a traditional diet each animal of group T1 was received, in addition to this traditional diet, 2g of Probiotic, and animal of group T2 were received 4g of Probiotics for each. Blood was collectedfrom the groups at the endofthe experiment tocarry blood picture (RBC, WBC, PCV, HB, DWBC and Cholesterol). The results of the search to a bloody and Cholesterol changes in the groups compared to the control. Our results showed the following: An increase in the value of (RBC, HB, PCV) compared to the control, but did not reach the increase to the level of significance. (WBC, DWBC) was not affected by adding probiotics to the diet of the Lambs. A significant decrease in the concentration of The cholesterol in groups (T1, T2) compared to the control (P<0.05).