The present field study was carried out to investigate the relationship between some ration components and blood biochemical constituents of broiler suffering from leg problems. A total of 128 broiler chicks (2, 3, 4 and 5 weeks of age) represented 8 farms were collected, 80 clinically affected (birds showed lameness, unable to stand, bowed legs, twisted, rotated, extended laterally legs) and 48 apparently healthy. Besides 8 ration contents from the same farms. Clinical signs and postmortem were done. Ration analysis for the nutritive constituents were carried out (dry matter - ash - fat -fiber - protein - calcium -phosphorous -manganese - zinc and copper). Serum samples were analyzed for calcium, phosphorous, manganese, zinc, copper, triglyceride, cholesterol, glucose and total protein. The results indicated that, a wide variation of nutrient contents was observed in the diet fed to broilers in different farms. An increase of calcium content at 2 weeks of age with wide calcium: phosphorus ratio (3.06:1, 2.64:1) in addition to marked imbalance of Ca:P ratios of most rations (0.84:1, 1.2:1, 1.1:1, 0.97:1,1.5:1 and 0.85:1). The birds reared on high dietary calcium and Low phosphorus revealed hypercalcaemia and hypophosphataemia in their sera. Feed sample contained relatively lower amount of CP (crude protein) which is  (16.63,16.98,15.59,15.15,15,14.75,14.69 and 13.30%) for farm F1,F2,F3,F4, F5,F6,F7 and F8 respectively, that not matched with protein requirement at each age. Disturbance in Mn, Zn and Cu contents in all farm groups. A significant differences (P<0.05) and (P<0.01) in values of the biochemical parameters within chickens of various ages were recorded. Comparison values of the biochemical parameters between groups revealed that values of calcium, phosphorous, total protein, Zn and Cu were significantly (P<0.05) differed from those values of corresponding biochemical parameters of apparently healthy chickens, triglyceride and cholesterol and glucose were significantly high, whilst Mn were significantly (P<0.01) lower in all affected chickens than apparently healthy ones. It could be concluded that, metabolic and management factors are involved in conditions of leg disorders in broilers. Deprivation in feed intake due to birds' immobility, suboptimal nutrition, feed ingredients quality, consumption and absorption moreover decrease bioavailability of some element and imbalance of others. Rations had positive effect on certain serum biochemical parameters of broiler chickens. The obtained results may be helpful in the evaluation of changes in the metabolic profile, health condition and production patterns in growing broiler chickens reared under farm conditions.