Fifty two adult native breed Egyptian sheep were suffering from ruminal indigestion. The animals were divided into three groups, based on clinical signs and ruminal pH. The number of diseased cases with ruminal acidosis were 20, ruminal alkalosis 17 and those with ruminal tympany 15. In addition, 12 clinically adult sheep were used as control. Most cases with ruminal indigestion showed partial or complete anorexia, loss of body condition, abdominal pain, cessation of rumination and abdominal distension. Such signs differ according to the disease condition. Ruminal samples were collected from all animals and transferred to the laboratory for biophysical and biochemical analysis. All samples collected from diseased cases showed changes in the microbial activity as indicated by retardation in times of SAT, MBRT and CDT. Also, the values (m1) of GFT were increased especially in cases with ruminal tympany. All cases with ruminal dysfunction showed reduction in values and percentages of total and differential protozoal count. Biochemical analysis of ruminal fluid revealed variations in the values of sodium, potassium, chlorides and lactates among the types of indigestion.