In order to investigate the effect of curcumin on treatment of Schistosoma mansoni infested mice. Forty, male CD-1 Swiss albino mice used in this experiment, divided equally into 4 groups, the first kept as control, the second supplemented with curcumin, the third infected with S.mansoni and the 4^th infected then treated with curcumin. The results emphasized on the presence of anemia leucopenia, neutropenia and esinophilia in infested groups either treated or not with somewhat an improvement in the treated group. The biochemical parameters showed that curcumin tries to restore the increased transaminases, alkaline phosphatase, antioxidants, triglycerides and low density lipoproteins to normal. Finally, curcumin treated group still closer to the infected group more than to the normal control group.