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170201

HEMATOLOGICAL AND BIOCHEMICAL ABNORMALITIES OF CANINE MAMMARY GLAND TUMORS CORRELATED TO THEIR HISTOPATHOLOGICAL TYPES AND SERUM BIOMARKERS.

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Last updated: 05 Jan 2025

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Abstract

In the present study, we tried to evaluate the existence of a relationship between CA 15–3 serum levels and mammary tumors in dogs correlated with heamatobiochemical and histopathological pictures. Blood and tissue samples were obtained from 31 mammary tumors bearing dogs, in addition to 5 apparently healthy dogs. The results revealed that the values of CA15–3 in healthy dogs were lower than in human, equal to ≥ 1u/ml  but in mammary tumors bearing dogs rose to 7~ 7.7 u/ml. No relationship between tumor markers (CA15-3), tumor size, presence of ulceration or histopathological type of tumor were found. Microcytic hypochromic anemia and sometimes leukocytosis especially neutrophilia were present with tumors. Unfortunately, the serum values of CA15-3 rose to 17 u/ml in animals suffering from other diseases. Pathological picture of the tumors showed that malignant cancers were of the highest percentage than benign tumours and revealed several different types of malignant cancers. Mixed and complex carcinoma were the most prominent types of mammary gland tumors of dogs. Immunohistochemical staining of estrogen receptors (ER) and progesterone receptors (PR) in canine mammary gland tumors showed benign fibrocystic disease positive for ER and PR. Tubulopapillary carcinoma was positive for (ER) and (PR). Anaplastic giant   carcinoma was positive for (PR) and negative for (ER). Mucinous carcinoma was positive for (ER) negative for (PR). Complex carcinoma showed very weak positive staining for (ER) negative (PR). Mixed Carcinoma was negative for both (PR) and (ER).

DOI

10.21608/avmj.2015.170201

Keywords

Key words: Canine mammary neoplasia, Serum biomarker, hematology, histopathology, Immunohistochemstry and Biochemistry

Authors

First Name

SHAHENAZ

Last Name

M.H. HASAN

MiddleName

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Affiliation

Pathology Department, Animal Health Research Institute, Alexandria Provincial Lab

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First Name

NAHEAD

Last Name

F. ZAGHLOL

MiddleName

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Affiliation

Biochemistry Department, Animal Health Research Institute, Alexandria Provincial Lab

Email

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City

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Orcid

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First Name

SANAA

Last Name

A. EL-SHAMY

MiddleName

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Affiliation

Veterinary Medicine Province, Alexandria Governorate.

Email

afyfi@yahoo.com

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Orcid

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First Name

DINA

Last Name

K. LATTEEF

MiddleName

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Affiliation

Veterinary Medicine Province, Alexandria Governorate.

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Volume

61

Article Issue

145

Related Issue

24323

Issue Date

2015-04-01

Receive Date

2015-02-24

Publish Date

2015-04-01

Page Start

178

Page End

200

Print ISSN

1012-5973

Online ISSN

2314-5226

Link

https://avmj.journals.ekb.eg/article_170201.html

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https://avmj.journals.ekb.eg/service?article_code=170201

Order

21

Type

Research article

Type Code

1,840

Publication Type

Journal

Publication Title

Assiut Veterinary Medical Journal

Publication Link

https://avmj.journals.ekb.eg/

MainTitle

HEMATOLOGICAL AND BIOCHEMICAL ABNORMALITIES OF CANINE MAMMARY GLAND TUMORS CORRELATED TO THEIR HISTOPATHOLOGICAL TYPES AND SERUM BIOMARKERS.

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Article

Created At

23 Jan 2023