The aim of this work was to find out how Oreochromis niloticus were fed diets containing T-2 toxins for a period of 42 days as well as study the role of efficacy of two mycotoxin adsorbents to alleviate T2 toxins -induced toxicity. The O. niloticus were treated with 1 g /kg from both Mycosorb (G1) and Zeolite (G2), 0.1 mg/kg of T-2 in (G3), 0.1 mg/kg of T-2 + 1 g/kg Mycosorb in (G4), 0.1 mg/kg of T-2 + 1 g/kg Zeolite in (G5) and control negative group feed on basal commercial ration (G6). T-2 toxins was dissolved in 10 ml/kg of 7% (DMSO). These doses were added to feed daily for a period of seven weeks. Some biochemical blood serum indicators of liver and kidney functions, and leucogram were monitored as well as histopathological picture of some internal organs. The results revealed an increase in the levels of liver enzymes, urea and creatinine; meanwhile, the total protein, Ca, P and Mg, were decreased. It could be concluded that both Mycosorb and Zeolite may be useful tool to minimize the toxic effects of T-2 toxicity by its potent antioxidant activity. The kidney plays an important physiological. Fish treated with both Mycosorb and Zeolite showed an amelioration of the adverse effects of T-2 toxicity and significant improvement in serum electrolytes (calcium, inorganic phosphate, and magnesium) and creatinine level compared with the positive control group (P < 0.05). Mycosorb and Zeolite have the ability to improve the kidney function after T-2 intoxication of O. niloticus.