The present study was carried out on a total number of 1106 cattle (females = 935 and males = 171) of an age varied between one year and eleven years. Animals were presented to the clinic within a range of 10 days of infection with different lesions of FMD outbreak occurred at April 2012 at Beni-Suef province, Egypt. The aim of the present study is to describe different lesions of foot and mouth disease (FMD) in cattle. The location and frequency of occurrence of lesions were recorded. Topical and systemic treatment was discussed as an alternative policy for control of FMD lesions in endemic countries. The main lesions of the affected cases were recorded in the dental bad (1053), tongue (1020), and inner aspect of the lower lip (713). A moderate number of lesions were recorded on the gum of lower jaw (318), coronary band and interdigital space (518) and teats (303). Lesions were seen in small number of cases on the muzzle (104), nostrils (17), and hard palate (15). Recovery of all lesions was obtained within 3-10 days with variable degree of scar tissue formation. Slight teat dysfunction and mastitis was supervene in 33 cases. Slight degree of lameness due to thimbling of the claws was recorded in 220 animals. Early management of FMD lesions decreases the economic losses and speeds returning of the animal to normal condition.