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170259

COMPARATIVE EFFECT OF METHALONIC EXTRACT OF SYRIAN FENUGREEK AND NIGELLA SATIVA SEEDS ON SOME BIOCHEMICAL PARAMETERS IN MALE DIABETIC RABBITS

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Last updated: 23 Jan 2023

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Abstract

Present study investigated the effect of methanolic extracts of Fenugreek and Nigella Sativa seeds on blood glucose, total cholesterol and triglyceride, LDL, HDL levels in alloxan diabetic rabbits. The experiment was carried out on 42 of Male rabbits divided into7 groups 6 animals of each: -The first group was kept as normal control. - The second group was given orally the methanolic extract of and Nigella Sativa seeds 1/10 LD50. -The third group was given orally the methanolic extract of Nigella Sativa seeds 1/5 LD50. - The forth group was given orally the methanolic extract of Fenugreek seeds 1/10 LD50. - The fifth group was given orally the methanolic extract of Fenugreek seeds 1/10 LD50. - The six group was rendered diabetic and treated with insulin. - The seven group was diabetic by intraperitoneal injection of alloxan (150 mg/kg b.wt.) and left without treatment. Blood samples were collected at 1,20,40,60 days for determination of glucose, total cholesterol, triglyceride, LDL and HDL levels. The obtained results showed that oral administration of methanolic extracts of methanolic extracts of Fenugreek and Nigella Sativa seeds induced significantly (p < 0.05) decreased blood glucose, total cholesterol, triglyceride and LDL in all remediation experiment groups Especially (third, fifth groups) comparative  to the diabetic control group,  Methanolic extracts of Fenugreek and Nigella Sativa seeds induced significantly (p < 0.05) increase in HDL in all remediation experiment groups especially (third and fifth groups) in comparative to the diabetic control group.

DOI

10.21608/avmj.2015.170259

Keywords

Key words: Nigella sativa, fenugreek, biochemical parameters

Authors

First Name

S.

Last Name

HOOR

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Affiliation

Department of Physiology Veterinary Faculty, Hama University, Syria

Email

hor.zkrya@gmail.com

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Orcid

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First Name

A.

Last Name

ALABBD

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-

Affiliation

Department of Physiology Veterinary Faculty, Hama University, Syria

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Volume

61

Article Issue

147

Related Issue

24321

Issue Date

2015-10-01

Receive Date

2015-08-12

Publish Date

2015-10-01

Page Start

15

Page End

28

Print ISSN

1012-5973

Online ISSN

2314-5226

Link

https://avmj.journals.ekb.eg/article_170259.html

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https://avmj.journals.ekb.eg/service?article_code=170259

Order

31

Type

Research article

Type Code

1,840

Publication Type

Journal

Publication Title

Assiut Veterinary Medical Journal

Publication Link

https://avmj.journals.ekb.eg/

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Article

Created At

23 Jan 2023