The present study aimed to describe radiographic changes in the proximal sesamoid bones in case of sesamoiditis in donkeys. The study was carried out on 16 fetlock joints selected from 14 adult donkeys suffering from lameness and painful swelling at the palmar (plantar) aspect of the fetlock joints. Radiographic examination of the fetlock joints were performed using four views to record changes in the proximal sesamoid bones. Results of the present study indicated that, sesamoiditis was diagnosed more commonly in the fore fetlock (68.75%) than the hind fetlock (31.25%). Radiographic findings in sesamoiditis were differentiated into abaxial osteolytic lesions (50.00%), periosteal new bone proliferations (43.75%) and focal area of osteolysis (6.25%). In conclusion, radiographic examination of the fetlock joint proved to be a valuable tool in diagnosis of sesamoiditis in donkeys.